Endocrine Abstracts

Vitamin D metabolites modulate creatine kinase specific activity (CK) in cultured skeletal cells. In this study we assess the effect of vitamin D metabolites on CK in rat epiphyseal cartilage (Ep) and diaphyseal bone (Di). Female or male Wistar- derived rats were used either as intact or after gonadectomy (Ovx or cast respectively), and treatments started 2 weeks post surgery. Rats were injected daily for 1, 2 or 8 weeks with the less-calcemic vitamin D analogs CB 1093 (CB), J...

We examined the response of rat female pituitary at different metabolic stages to treatments with estrogenic compounds and vitamin D analogs. Immature or ovariectomized (Ovx) female rats, responded by increased creatine kinase specific activity (CK) to estradiol-17β (E2), genistein (G), daidzein (D), biochainin A (BA), quecertin (Qu), carboxy- G (cG), carboxy- BA (cBA) and raloxifene (Ral). The response was inhibited when Ral was injected together with the estr...

Vitamin D receptors are widely expressed in the skeletal system, and vitamin D and its metabolites and analogs, exert a variety of biological activities such as regulation of cellular proliferation and differentiation, cell calcium transients and energy metabolism in vitro. The latter is exerted through the control of the brain type isozyme of creatine kinase specific activity (CK), which serves to provide a readily available reservoir for ATP generation under increased worklo...